Hypertension with Type 2 Diabetic Nephropathy

Once diabetic nephropathy has progressed to end-stage renal disease (ESRD), other than kidney transplantation there is no treatment that effectively restores renal function after the onset of ESRD.²⁶

Higher blood pressure levels are associated with faster declines in glomerular filtration rate (GFR), and strict control of blood pressure slows the progression of chronic kidney disease.²⁶

Several guidelines offer recommendations for ARBs for the management of diabetic nephropathy due to type 2 diabetes

They are as follows:

Guidelines for Type 2 Diabetic Nephropathy

1. Chobanian AV et al. Hypertension. 2003;42:1206-1252.
27. American Diabetes Association. Diabetes Care. 2008;31:S12-S54.
28. Adapted from Kidney Disease Outcomes Quality Initiative K/DOQI. Am J Kidney Disease. 2007;49(suppl 2):S1-S180.

WARNING: USE IN PREGNANCY When pregnancy is detected, discontinue AVAPRO or AVALIDE as soon as possible. When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. [See Warnings and Precautions: Fetal/Neonatal Morbidity and Mortality in the full Prescribing Information.]

Please see Indications and Important Safety Information.

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